How to set up a self hosted WordPress blog as a screen reader user

I have seen lots of visually impaired people hunting across the internet for any information about WordPress and its accessibility for screen reader users. Also, the numerous practical questions involved about its performance in carrying out an assortment of tasks under a WordPress blog without a satisfactory answer.
Because of this, I have decided to start up a new serie of podcast named WordPress for Blind.
I will take on the task to make a blog from scratch.
To be more precise, I will buy a domain name, put on hosting, install WordPress, customise it, and then carry out the heavy work, publishing content.